منابع مشابه
Biomarkers predictive of GSI response in solid tumors
Merck Research Laboratory, Boston MA 02115. Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115. Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadephia, PA 19104. Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, MA 02114. Department of Medicine and Digestive Health R...
متن کاملImmune microenvironments in solid tumors: new targets for therapy.
Leukocytes and their soluble mediators play important regulatory roles in all aspects of solid tumor development. While immunotherapeutic strategies have conceptually held clinical promise, with the exception of a small percentage of patients, they have failed to demonstrate effective, consistent, and durable anti-cancer responses. Several subtypes of leukocytes that commonly infiltrate solid t...
متن کاملNumerical Modeling of Fluid Flow in Solid Tumors
A mathematical model of interstitial fluid flow is developed, based on the application of the governing equations for fluid flow, i.e., the conservation laws for mass and momentum, to physiological systems containing solid tumors. The discretized form of the governing equations, with appropriate boundary conditions, is developed for a predefined tumor geometry. The interstitial fluid pressure a...
متن کاملGuidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria.
PURPOSE Immunotherapeutic agents produce antitumor effects by inducing cancer-specific immune responses or by modifying native immune processes. Resulting clinical response patterns extend beyond those of cytotoxic agents and can manifest after an initial increase in tumor burden or the appearance of new lesions (progressive disease). Response Evaluation Criteria in Solid Tumors or WHO criteria...
متن کاملMCL1 and BCL-xL Levels in Solid Tumors Are Predictive of Dinaciclib-Induced Apoptosis
Dinaciclib is a potent CDK1, 2, 5 and 9 inhibitor being developed for the treatment of cancer. Additional understanding of antitumor mechanisms and identification of predictive biomarkers are important for its clinical development. Here we demonstrate that while dinaciclib can effectively block cell cycle progression, in vitro and in vivo studies, coupled with mouse and human pharmacokinetics, ...
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ژورنال
عنوان ژورنال: Journal of Visualized Experiments
سال: 2020
ISSN: 1940-087X
DOI: 10.3791/60645